Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice

Osteoarthritis (OA), a common degenerative joint disease, is principally characterized by inflammation and destruction of cartilage. Nobiletin, an extract of the peel of citrus fruits, is known to have anti-inflammatory properties. However, the mechanisms by which nobiletin plays a protective role i...

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Bibliographic Details
Main Authors: Zeng Lin, Dengying Wu, Lipeng Huang, Chao Jiang, Tianlong Pan, Xiaodiao Kang, Jun Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
nobiletin
osteoarthritis
interleukin-1β
chondrocyte
inflammation
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00570/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00570/full

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