Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyloid-β (Aβ) fragments in the brain by modulation of γ...

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Bibliographic Details
Main Authors: Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner, Evamarie Hey-Hawkins
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
Alzheimer
carborane
flurbiprofen
γ-secretase modulator (GSM)
small molecule
amyloid-β (Aβ) peptide
Online Access:https://www.mdpi.com/1420-3049/26/10/2843

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https://www.mdpi.com/1420-3049/26/10/2843

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