Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function

Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function

Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Parkin (which encoded by Park2), an E3 ubiquitin ligase, is the most frequently mutated gene that has casually been linked to autosomal recessive earl...

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Bibliographic Details
Main Authors: Chul Ju Hwang, Young Eun Kim, Dong Ju Son, Mi Hee Park, Dong-Young Choi, Pil-Hoon Park, Mats Hellström, Sang-Bae Han, Ki-Wan Oh, Eun Kyung Park, Jin Tae Hong
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716302440

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http://www.sciencedirect.com/science/article/pii/S2213231716302440

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