Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

Abstract Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We here show that USP39, a component of the spliceosome, is frequently overexpressed in...

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Bibliographic Details
Main Authors: Shourong Wang, Zixiang Wang, Jieyin Li, Junchao Qin, Jianping Song, Yingwei Li, Ling Zhao, Xiyu Zhang, Haiyang Guo, Changshun Shao, Beihua Kong, Zhaojian Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03581-3

Internet

https://doi.org/10.1038/s41419-021-03581-3

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