S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration

S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration

IntroductionIn multiple sclerosis (MS), chronic disability primarily stems from axonal and neuronal degeneration, a condition resistant to conventional immunosuppressive or immunomodulatory treatments. Recent research has indicated that selective sphingosine-1-phosphate receptor S1PR-1 and -5 modula...

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Bibliographic Details
Main Authors: Mustafa Sindi, Christina Hecker, Andrea Issberner, Tobias Ruck, Sven G. Meuth, Philipp Albrecht, Michael Dietrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
S1PR-1
S1PR-5
RP-101074
neuroprotection
multiple sclerosis
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234984/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234984/full

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