A Foundational Study for Normal <i>F8</i>-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine <i>F8</i> Gene

A Foundational Study for Normal <i>F8</i>-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine <i>F8</i> Gene

Hemophilia A (HA) is associated with defects in the <i>F8</i> gene, encoding coagulation factor VIII (FVIII). Our previous studies show that F8-targeting micro RNAs (miRNAs), a group of small RNAs involved in gene regulation, can downregulate F8 expression causing HA in individuals with...

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Bibliographic Details
Main Authors: Katarzyna I. Jankowska, Maitreyi Chattopadhyay, Zuben E. Sauna, Chintamani D. Atreya
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
microRNAs (miRNAs)
bleeding disorders
coagulation factors
hemophilia A
mouse model
Online Access:https://www.mdpi.com/1422-0067/21/16/5621

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https://www.mdpi.com/1422-0067/21/16/5621

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