Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement; in vitro and in vivo assessment

Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability enhancement; in vitro and in vivo assessment

Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by incorporating into self-emulsifying micelles (SEMCs). To fabricate the SEM...

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Bibliographic Details
Main Authors: Nayyer Islam, Naveed Ullah Khan, Anam Razzaq, Zaheer Ullah Khan, Farid Menaa, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Haroon Iqbal, Jiang Ni
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Itraconazole
Gelucire44/14
Gelucire 50/13
Solubility
Dissolution rate
Bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423003341

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http://www.sciencedirect.com/science/article/pii/S1319016423003341

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