Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

Abstract One of the therapeutic approaches for the treatment of the autoimmune demyelinating disease, multiple sclerosis (MS) is bone marrow mesenchymal stromal cell (hBM-MSCs) transplantation. However, given their capacity to enhance myelination in vitro, we hypothesised that human olfactory mucosa...

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Bibliographic Details
Main Authors: Susan L. Lindsay, Aleksandra M. Molęda, Lindsay M. MacLellan, Siew Min Keh, Daniel E. McElroy, Christopher Linington, Carl S. Goodyear, Susan C. Barnett
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Acta Neuropathologica Communications
Subjects:
Human mesenchymal stromal cells
Olfactory mucosa
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Myelination
Interleukin 16
Online Access:https://doi.org/10.1186/s40478-022-01316-9

Internet

https://doi.org/10.1186/s40478-022-01316-9

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