Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure
Introduction: Inhaled budesonide is a novel approach to prevent acute mountain sickness (AMS). However, its mechanism is not completely understood. We aimed to investigate the effects of budesonide and dexamethasone on renin–angiotensin–aldosterone system in AMS prevention. Materials and methods: Da...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2016-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320316653867 |
| _version_ | 1797282636617482240 |
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| author | Hui-Jie Li Cheng-Rong Zheng Guo-Zhu Chen Jun Qin Ji-Hang Zhang Jie Yu En-Hao Zhang Lan Huang |
| author_facet | Hui-Jie Li Cheng-Rong Zheng Guo-Zhu Chen Jun Qin Ji-Hang Zhang Jie Yu En-Hao Zhang Lan Huang |
| author_sort | Hui-Jie Li |
| collection | DOAJ |
| description | Introduction: Inhaled budesonide is a novel approach to prevent acute mountain sickness (AMS). However, its mechanism is not completely understood. We aimed to investigate the effects of budesonide and dexamethasone on renin–angiotensin–aldosterone system in AMS prevention. Materials and methods: Data were obtained from a randomised controlled trial including 138 participants. The participants were randomly assigned to receive budesonide, dexamethasone or placebo as prophylaxis before they travelled to 3450 m altitude from 400 m by car. Their plasma concentrations of renin, angiotensin-converting enzyme (ACE) and aldosterone were measured at both altitudes. Results: All parameters were comparable among the three groups at 400 m. After high-altitude exposure of 3450, renin in all groups increased significantly; the ACE, aldosterone concentrations, as well as the aldosterone/renin ratio, rose markedly in the dexamethasone and placebo groups but not in the budesonide group. Moreover, the aldosterone/renin ratio correlated closely with ACE concentration. Conclusions: Upon acute high-altitude exposure, budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme. |
| first_indexed | 2024-03-07T17:17:14Z |
| format | Article |
| id | doaj.art-954c377b592e4c10afeafdaf4f791634 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:17:14Z |
| publishDate | 2016-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-954c377b592e4c10afeafdaf4f7916342024-03-02T22:03:04ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762016-06-011710.1177/1470320316653867Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposureHui-Jie Li0Cheng-Rong Zheng1Guo-Zhu Chen2Jun Qin3Ji-Hang Zhang4Jie Yu5En-Hao Zhang6Lan Huang7Institute of Cardiovascular Science, Third Military Medical University, ChinaDepartment of Cardiovascular Science, The General Hospital of the People’s Liberation Army (PLA) Rocket Force, ChinaPLA Institute of Cardiovascular Disease, ChinaPLA Institute of Cardiovascular Disease, ChinaPLA Institute of Cardiovascular Disease, ChinaPLA Institute of Cardiovascular Disease, ChinaInstitute of Cardiovascular Science, Third Military Medical University, ChinaPLA Institute of Cardiovascular Disease, ChinaIntroduction: Inhaled budesonide is a novel approach to prevent acute mountain sickness (AMS). However, its mechanism is not completely understood. We aimed to investigate the effects of budesonide and dexamethasone on renin–angiotensin–aldosterone system in AMS prevention. Materials and methods: Data were obtained from a randomised controlled trial including 138 participants. The participants were randomly assigned to receive budesonide, dexamethasone or placebo as prophylaxis before they travelled to 3450 m altitude from 400 m by car. Their plasma concentrations of renin, angiotensin-converting enzyme (ACE) and aldosterone were measured at both altitudes. Results: All parameters were comparable among the three groups at 400 m. After high-altitude exposure of 3450, renin in all groups increased significantly; the ACE, aldosterone concentrations, as well as the aldosterone/renin ratio, rose markedly in the dexamethasone and placebo groups but not in the budesonide group. Moreover, the aldosterone/renin ratio correlated closely with ACE concentration. Conclusions: Upon acute high-altitude exposure, budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme.https://doi.org/10.1177/1470320316653867 |
| spellingShingle | Hui-Jie Li Cheng-Rong Zheng Guo-Zhu Chen Jun Qin Ji-Hang Zhang Jie Yu En-Hao Zhang Lan Huang Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure Journal of the Renin-Angiotensin-Aldosterone System |
| title | Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure |
| title_full | Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure |
| title_fullStr | Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure |
| title_full_unstemmed | Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure |
| title_short | Budesonide, but not dexamethasone, blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high-altitude exposure |
| title_sort | budesonide but not dexamethasone blunted the response of aldosterone to renin elevation by suppressing angiotensin converting enzyme upon high altitude exposure |
| url | https://doi.org/10.1177/1470320316653867 |
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