Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice

Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and diabetes. sn-Glycerol-3-phosphate acyltransferase (GPAT) and sn-1-acylglycerol-3-phosphate acyltransferase (AGPAT) cat...

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Bibliographic Details
Main Authors: Cynthia A. Nagle, Laurent Vergnes, Hendrik DeJong, Shuli Wang, Tal M. Lewin, Karen Reue, Rosalind A. Coleman
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Journal of Lipid Research
Subjects:
triacylglycerol
phospholipid
lipodystrophy
acyl-coenzyme A
steatosis
sn-1-acylglycerol-3-phosphate O-acyltransferase-deficient mice
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042396X

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http://www.sciencedirect.com/science/article/pii/S002222752042396X

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