Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling significantly enhances responsiveness of pancreatic du...

Full description

Bibliographic Details
Main Authors: Sruthi Ravindranathan, Tenzin Passang, Jian-Ming Li, Shuhua Wang, Rohan Dhamsania, Michael Brandon Ware, Mohammad Y. Zaidi, Jingru Zhu, Maria Cardenas, Yuan Liu, Sanjeev Gumber, Brian Robinson, Anish Sen-Majumdar, Hanwen Zhang, Shanmuganathan Chandrakasan, Haydn Kissick, Alan B. Frey, Susan N. Thomas, Bassel F. El-Rayes, Gregory B. Lesinski, Edmund K. Waller
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34242-4

Internet

https://doi.org/10.1038/s41467-022-34242-4

Similar Items