Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer

In this work, the natural piperine moiety was utilised to develop two sets of piperine-based amides (5a–i) and ureas (8a–y) as potential anticancer agents. The anticancer action was assessed against triple negative breast cancer (TNBC) MDA-MB-231, ovarian A2780CP and hepatocellular HepG2 cancer cell...

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Bibliographic Details
Main Authors: Diaaeldin M. Elimam, Abdullah A. Elgazar, Fardous F. El-Senduny, Ramadan A. El-Domany, Farid A Badria, Wagdy M. Eldehna
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Online Access:http://dx.doi.org/10.1080/14756366.2021.1988944