Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart.
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood. When functioning normally, mature heart valves prevent intracardiac retrograde blood flow; before valves develop, there i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2773122?pdf=render |