Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications

Synthesis of 1-(2'-O-Methyl-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione: An Attractive Building Block for Antisense and Triple-helical Applications

Synthesis of the title compound,1-(2'-O-methyl-ß-D-ribofuranosyl)-1H-imidazo-[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in four steps, starting from methyl 1-(ß-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 was protect...

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Bibliografiska uppgifter
Huvudupphovsmän: Ramachandra S. Hosmane, Huan-Ming Chen
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2001-02-01
Serie:Molecules
Ämnen:
Synthesis
Nucleoside Analogue
Imidazo[4
5-d]pyridazine
2'-O-Methyl Nucleoside Introduction
Länkar:http://www.mdpi.com/1420-3049/6/3/203/

Internet

http://www.mdpi.com/1420-3049/6/3/203/

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