Bcl-xL Reduces Chinese Giant Salamander Iridovirus-Induced Mitochondrial Apoptosis by Interacting with Bak and Inhibiting the p53 Pathway

Bcl-xL Reduces Chinese Giant Salamander Iridovirus-Induced Mitochondrial Apoptosis by Interacting with Bak and Inhibiting the p53 Pathway

Chinese giant salamander iridovirus (GSIV) infection could lead to mitochondrial apoptosis in this animal, a process that involves B-cell lymphoma-2 (BCL-2) superfamily molecules. The mRNA expression level of Bcl-xL, a crucial antiapoptotic molecule in the BCL-2 family, was reduced in early infectio...

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Bibliographic Details
Main Authors: Yiqun Li, Yuding Fan, Yong Zhou, Nan Jiang, Mingyang Xue, Yan Meng, Wenzhi Liu, Jingjing Zhang, Ge Lin, Lingbing Zeng
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Viruses
Subjects:
Bcl-xL
chinese giant salamander iridovirus
mitochondria
apoptosis
Bak
p53
Online Access:https://www.mdpi.com/1999-4915/13/11/2224

Internet

https://www.mdpi.com/1999-4915/13/11/2224

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