Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.

Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43) within the CNS is a pathological hallmark in spora...

Full description

Bibliographic Details
Main Authors: Yoshitaka Tamaki, Jay P Ross, Paria Alipour, Charles-Étienne Castonguay, Boting Li, Helene Catoire, Daniel Rochefort, Makoto Urushitani, Ryosuke Takahashi, Joshua A Sonnen, Stefano Stifani, Patrick A Dion, Guy A Rouleau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010606

Internet

https://doi.org/10.1371/journal.pgen.1010606

Similar Items