Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli

Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli

The indole-diterpene paxilline is an abundant secondary metabolite synthesized by Penicillium paxilli. In total, 21 genes have been identified at the PAX locus of which six have been previously confirmed to have a functional role in paxilline biosynthesis. A combination of bioinformatics, gene expre...

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Bibliographic Details
Main Authors: Emily J. Parker, Brian A. Tapper, Sarah C. Finch, Ruth E. Wrenn, Andrea Bryant, Carla J. Eaton, Albert Koulman, Jonathan Astin, Brendon J. Monahan, Sanjay Saikia, Lisa K. McMillan, Carolyn A. Young, Geoffrey B. Jameson, Barry Scott
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Toxins
Subjects:
indole-diterpene
paxilline
prenylation
Online Access:http://www.mdpi.com/2072-6651/5/8/1422

Internet

http://www.mdpi.com/2072-6651/5/8/1422

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