Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption
Oral drug delivery to treat diabetes is being increasingly researched. The mucus and the epithelial cell layers hinder drug delivery. We designed a self-ablating nanoparticle to achieve smart oral delivery to overcome the gastrointestinal barrier. We used the zwitterionic dilauroyl phosphatidylcholi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2021.2023704 |
| _version_ | 1798015866944618496 |
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| author | Yanzi Liang Ruihuan Ding Huihui Wang Lanze Liu Jibiao He Yuping Tao Zhenyu Zhao Jie Zhang Aiping Wang Kaoxiang Sun Youxin Li Yanan Shi |
| author_facet | Yanzi Liang Ruihuan Ding Huihui Wang Lanze Liu Jibiao He Yuping Tao Zhenyu Zhao Jie Zhang Aiping Wang Kaoxiang Sun Youxin Li Yanan Shi |
| author_sort | Yanzi Liang |
| collection | DOAJ |
| description | Oral drug delivery to treat diabetes is being increasingly researched. The mucus and the epithelial cell layers hinder drug delivery. We designed a self-ablating nanoparticle to achieve smart oral delivery to overcome the gastrointestinal barrier. We used the zwitterionic dilauroyl phosphatidylcholine, which exhibits a high affinity toward Oligopeptide transporter 1, to modify poly(lactic-co-glycolic acid) nanoparticles and load hemagglutinin-2 peptide to facilitate its escape from lysosomes. Nanoparticles exhibit a core–shell structure, the lipid layer is degraded by the lysosomes when the nanoparticles are captured by lysosomes, then the inner core of the nanoparticles gets exposed. The results revealed that the self-ablating nanoparticles exhibited higher encapsulation ability than the self-assembled nanoparticles (77% vs 64%) and with better stability. Quantitative cellular uptake, cellular uptake mechanisms, and trans-monolayer cellular were studied, and the results revealed that the cellular uptake achieved using the self-ablating nanoparticles was higher than self-assembling nanoparticles, and the number of uptake pathways via which the self-ablating nanoparticles functioned were higher than the self-assembling nanoparticles. Intestinal mucus permeation, in vivo intestinal circulation, was studied, and the results revealed that the small self-assembling nanoparticles exhibit a good extent of intestinal uptake in the presence of mucus. In vitro flip-flop, intestinal circulation revealed that the uptake of the self-ablating nanoparticles was 1.20 times higher than the self-assembled nanoparticles. Pharmacokinetic study and the pharmacodynamic study showed that the bioavailability and hypoglycemic effect of self-ablating nanoparticles were better than self-assembled nanoparticles. |
| first_indexed | 2024-04-11T15:41:36Z |
| format | Article |
| id | doaj.art-9558765b16e14ea6a28354b8dcaa8ab5 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-11T15:41:36Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-9558765b16e14ea6a28354b8dcaa8ab52022-12-22T04:15:48ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-0129130531510.1080/10717544.2021.20237042023704Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorptionYanzi Liang0Ruihuan Ding1Huihui Wang2Lanze Liu3Jibiao He4Yuping Tao5Zhenyu Zhao6Jie Zhang7Aiping Wang8Kaoxiang Sun9Youxin Li10Yanan Shi11School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Life Science, Yantai UniversitySchool of Life Science, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Life Science, Yantai UniversitySchool of Life Science, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai UniversitySchool of Life Science, Yantai UniversityOral drug delivery to treat diabetes is being increasingly researched. The mucus and the epithelial cell layers hinder drug delivery. We designed a self-ablating nanoparticle to achieve smart oral delivery to overcome the gastrointestinal barrier. We used the zwitterionic dilauroyl phosphatidylcholine, which exhibits a high affinity toward Oligopeptide transporter 1, to modify poly(lactic-co-glycolic acid) nanoparticles and load hemagglutinin-2 peptide to facilitate its escape from lysosomes. Nanoparticles exhibit a core–shell structure, the lipid layer is degraded by the lysosomes when the nanoparticles are captured by lysosomes, then the inner core of the nanoparticles gets exposed. The results revealed that the self-ablating nanoparticles exhibited higher encapsulation ability than the self-assembled nanoparticles (77% vs 64%) and with better stability. Quantitative cellular uptake, cellular uptake mechanisms, and trans-monolayer cellular were studied, and the results revealed that the cellular uptake achieved using the self-ablating nanoparticles was higher than self-assembling nanoparticles, and the number of uptake pathways via which the self-ablating nanoparticles functioned were higher than the self-assembling nanoparticles. Intestinal mucus permeation, in vivo intestinal circulation, was studied, and the results revealed that the small self-assembling nanoparticles exhibit a good extent of intestinal uptake in the presence of mucus. In vitro flip-flop, intestinal circulation revealed that the uptake of the self-ablating nanoparticles was 1.20 times higher than the self-assembled nanoparticles. Pharmacokinetic study and the pharmacodynamic study showed that the bioavailability and hypoglycemic effect of self-ablating nanoparticles were better than self-assembled nanoparticles.http://dx.doi.org/10.1080/10717544.2021.2023704oral drug deliveryzwitterionic materialsself-ablating nanoparticlecellular uptakeintestinal absorption |
| spellingShingle | Yanzi Liang Ruihuan Ding Huihui Wang Lanze Liu Jibiao He Yuping Tao Zhenyu Zhao Jie Zhang Aiping Wang Kaoxiang Sun Youxin Li Yanan Shi Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption Drug Delivery oral drug delivery zwitterionic materials self-ablating nanoparticle cellular uptake intestinal absorption |
| title | Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption |
| title_full | Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption |
| title_fullStr | Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption |
| title_full_unstemmed | Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption |
| title_short | Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption |
| title_sort | orally administered intelligent self ablating nanoparticles a new approach to improve drug cellular uptake and intestinal absorption |
| topic | oral drug delivery zwitterionic materials self-ablating nanoparticle cellular uptake intestinal absorption |
| url | http://dx.doi.org/10.1080/10717544.2021.2023704 |
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