Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Abstract Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors, such as the O-biphenyl-3-yl carbamate URB597, have been shown to produce anti-hyperalgesic effects in animal models of migraine. The...

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Bibliographic Details
Main Authors: Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Angelo Reggiani, Natalia Realini, Rita Scarpelli, Daniele Piomelli, Cristina Tassorelli
Format: Article
Language:English
Published: BMC 2022-07-01
Series:The Journal of Headache and Pain
Subjects:
FAAH inhibitors
NTG
Trigeminal hyperalgesia
Lipid-derived mediators
Online Access:https://doi.org/10.1186/s10194-022-01449-1

Internet

https://doi.org/10.1186/s10194-022-01449-1

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