Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.

Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.

Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids, triggering sister chromatid separation. Separase is...

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Bibliographic Details
Main Authors: Noel Lianga, Carole Doré, Erin K Kennedy, Elaine Yeh, Elizabeth C Williams, Camille Marie Fortinez, Alick Wang, Kerry S Bloom, Adam D Rudner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5880407?pdf=render

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http://europepmc.org/articles/PMC5880407?pdf=render

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