Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development

Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show cancer-associated metabolic characteristics such as increased aerobic glycolysis...

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Bibliographic Details
Main Authors: Claire M. Larrieu, Simon Storevik, Joris Guyon, Antonio C. Pagano Zottola, Cyrielle L. Bouchez, Marie-Alix Derieppe, Tuan Zea Tan, Hrvoje Miletic, James Lorens, Karl Johan Tronstad, Thomas Daubon, Gro Vatne Røsland
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
pyruvate dehydrogenase kinases
DCA
glioblastoma
invasion
lactate
Online Access:https://www.mdpi.com/2072-6694/14/15/3769

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https://www.mdpi.com/2072-6694/14/15/3769

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