Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps

Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps

IntroductionNeutrophil extracellular traps (NETs) clear pathogens but may contribute Q8 pathogenically to host inflammatory tissue damage during sepsis. Innovative therapeutic agents targeting NET formation and their potentially harmful collateral effects remain understudied.MethodsWe investigated a...

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Bibliographic Details
Main Authors: Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, James M. Fulcher, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
sepsis
neutrophil
neutrophil extracellular trap
neonatal NET-Inhibitory Factor
cecal ligation and puncture
microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046574/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046574/full

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