Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15066-6 |