Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15066-6 |
| _version_ | 1819194782153441280 |
|---|---|
| author | Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears |
| author_facet | Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears |
| author_sort | Charandeep Singh |
| collection | DOAJ |
| description | Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium. |
| first_indexed | 2024-12-23T02:02:20Z |
| format | Article |
| id | doaj.art-956377e5821140ba84212046f44f2ab9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:02:20Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-956377e5821140ba84212046f44f2ab92022-12-21T18:03:58ZengNature PortfolioNature Communications2041-17232020-03-0111111110.1038/s41467-020-15066-6Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cellsCharandeep Singh0Vincent Tran1Leah McCollum2Youstina Bolok3Kristin Allan4Alex Yuan5George Hoppe6Henri Brunengraber7Jonathan E. Sears8Ophthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicOphthalmic Research, Cole Eye Institute, Cleveland ClinicDepartment of Nutrition, Case Western Reserve School of Medicine ClevelandOphthalmic Research, Cole Eye Institute, Cleveland ClinicPrematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.https://doi.org/10.1038/s41467-020-15066-6 |
| spellingShingle | Charandeep Singh Vincent Tran Leah McCollum Youstina Bolok Kristin Allan Alex Yuan George Hoppe Henri Brunengraber Jonathan E. Sears Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells Nature Communications |
| title | Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells |
| title_full | Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells |
| title_fullStr | Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells |
| title_full_unstemmed | Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells |
| title_short | Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells |
| title_sort | hyperoxia induces glutamine fuelled anaplerosis in retinal muller cells |
| url | https://doi.org/10.1038/s41467-020-15066-6 |
| work_keys_str_mv | AT charandeepsingh hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT vincenttran hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT leahmccollum hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT youstinabolok hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT kristinallan hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT alexyuan hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT georgehoppe hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT henribrunengraber hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells AT jonathanesears hyperoxiainducesglutaminefuelledanaplerosisinretinalmullercells |