Sleeping beauty generated CD19 CAR T-Cell therapy for advanced B-Cell hematological malignancies

Sleeping beauty generated CD19 CAR T-Cell therapy for advanced B-Cell hematological malignancies

Chimeric antigen receptor (CAR) T-cell therapy has emerged recently as a standard of care treatment for patients with relapsed or refractory acute lymphoblastic leukemia (ALL) and several subtypes of B-cell non-Hodgkin lymphoma (NHL). However, its use remains limited to highly specialized centers, g...

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Bibliographic Details
Main Authors: Harjeet Singh, Samer A. Srour, Denái R. Milton, Jessica McCarty, Cuiping Dai, Mahmoud R. Gaballa, Mariam Ammari, Simon Olivares, Helen Huls, Eleanor De Groot, David Marin, Demetrios Petropoulos, Amanda L. Olson, Paolo Anderlini, Jin S. Im, Issa Khouri, Chitra M. Hosing, Katayoun Rezvani, Richard E. Champlin, Elizabeth J. Shpall, Laurence J. N. Cooper, Partow Kebriaei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
sleeping beauty
non-viral gene transfer
CD19
CAR
T cells
lymphoid malignancy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032397/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032397/full

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