The plot thickens: OTULIN regulation in cell death
We recently demonstrated that post-translational modifications of the OTU deubiquitinase with linear linkage specificity (OTULIN) regulate its function in cell death. OTULIN hyper-phosphorylation promotes necroptosis by locking ring finger protein 31 (RNF31, also known as HOIP) away from the cylindr...
Main Authors: | Todd Douglas, Maya Saleh |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2020-07-01
|
Series: | Molecular & Cellular Oncology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/23723556.2020.1740541 |
Similar Items
-
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS
by: Julia Zinngrebe, et al.
Published: (2022-03-01) -
Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray
by: Lijie Zhou, et al.
Published: (2021-06-01) -
Linear Ubiquitin Chains: Cellular Functions and Strategies for Detection and Quantification
by: Gunnar Dittmar, et al.
Published: (2020-01-01) -
Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men
by: Nieves Peltzer, et al.
Published: (2022-06-01) -
Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase
by: Yasuhiro Fuseya, et al.
Published: (2021-10-01)