Japanese Encephalitis Virus Persistence in Porcine Tonsils Is Associated With a Weak Induction of the Innate Immune Response, an Absence of IFNγ mRNA Expression, and a Decreased Frequency of CD4+CD8+ Double-Positive T Cells

Japanese Encephalitis Virus Persistence in Porcine Tonsils Is Associated With a Weak Induction of the Innate Immune Response, an Absence of IFNγ mRNA Expression, and a Decreased Frequency of CD4+CD8+ Double-Positive T Cells

In humans, Japanese encephalitis virus (JEV) causes a devastating neurotropic disease with high mortality, whereas in pigs, the virus only causes mild symptoms. Besides tropism to the central nervous system, JEV seems to harbor a particular tropism for the tonsils in pigs. This secondary lymphoid or...

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Bibliographic Details
Main Authors: Valerie Redant, Herman W. Favoreel, Kai Dallmeier, Willem Van Campe, Nick De Regge
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Japanese encephalitis virus (JEV)
tonsils
persistence
CD4+CD8+ double-positive T cells
IFNγ
cell-mediated immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.834888/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.834888/full

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