Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity

Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity

The antimicrobial peptide (AMP) ARV-1502 was designed based on naturally occurring short proline-rich AMPs, including pyrrhocoricin and drosocin. Identification of chaperone DnaK as a therapeutic target in Escherichia coli triggered intense research on the ligand-DnaK-interactions using fluorescence...

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Bibliographic Details
Main Authors: Alexandra Brakel, Lisa Kolano, Carl N. Kraus, Laszlo Otvos, Ralf Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Chemistry
Subjects:
proline-rich antimicrobial peptide (PrAMP)
Chex1-Arg20
70 kDa heat shock protein DnaK
co-chaperones DnaJ and GrpE
ATPase activity
refolding
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.798006/full

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https://www.frontiersin.org/articles/10.3389/fchem.2022.798006/full

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