Comorbidity between epilepsy and depression: Role of hippocampal interleukin-1β

Comorbidity between epilepsy and depression: Role of hippocampal interleukin-1β

Depression is a frequent comorbidity of temporal lobe epilepsy (TLE); however, its mechanisms remain poorly understood and effective therapies are lacking. Augmentation of hippocampal interleukin-1β (IL-1β) signaling may be a mechanistic factor of both TLE and clinical depression. We examined whethe...

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Bibliographic Details
Main Authors: Andrey M. Mazarati, Eduardo Pineda, Don Shin, Delia Tio, Anna N. Taylor, Raman Sankar
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Neurobiology of Disease
Subjects:
Temporal lobe epilepsy
Depression
Comorbidity
Brain inflammation
Interleukin-1β
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900312X

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http://www.sciencedirect.com/science/article/pii/S096999610900312X

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