Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation

Downregulation of the vitamin D receptor expression during acute gastrointestinal graft versus host disease is associated with poor outcome after allogeneic stem cell transplantation

The vitamin D receptor (VDR) is critical in regulating intestinal homeostasis and emerging evidence demonstrates that VDR deficiency is a critical factor in inflammatory bowel disease pathology. However, no clinical data exist regarding the intestinal expression of VDR in patients after allogeneic h...

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Détails bibliographiques
Auteurs principaux: Carina Matos, Andreas Mamilos, Pranali N. Shah, Elisabeth Meedt, Daniela Weber, Saroj Ghimire, Andreas Hiergeist, André Gessner, Anne Dickinson, Ralf Dressel, Lutz Walter, Klaus Stark, Iris M. Heid, Hendrik Poeck, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Ernst Holler, Marina Kreutz, Sakhila Ghimire
Format: Article
Langue:English
Publié: Frontiers Media S.A. 2022-10-01
Collection:Frontiers in Immunology
Sujets:
VDR
HSCT
acute GI-GvHD
TRM
defensins
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028850/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028850/full

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