Hydroxytyrosol–Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer’s Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells

Hydroxytyrosol–Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer’s Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells

Alzheimer’s disease (AD) is the most common neurodegenerative pathology among progressive dementias, and it is characterized by the accumulation in the brain of extracellular aggregates of beta-amyloid proteins and neurofibrillary intracellular tangles consisting of τ-hyperphosphorylated proteins. U...

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Bibliographic Details
Main Authors: Jessica Maiuolo, Paola Costanzo, Mariorosario Masullo, Antonio D’Errico, Rosarita Nasso, Sonia Bonacci, Vincenzo Mollace, Manuela Oliverio, Rosaria Arcone
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease (AD)
donepezil
hybrid compounds
polyphenols
BACE-1
fibrillogenesis
Online Access:https://www.mdpi.com/1422-0067/24/17/13461

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https://www.mdpi.com/1422-0067/24/17/13461

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