Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Abstract Background Research in recent years firmly established that microglial cells play an important role in the pathogenesis of Alzheimer's disease (AD). In parallel, a series of studies showed that, under both homeostatic and pathological conditions, microglia are a heterogeneous cell popu...

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Main Authors: Anne-Laure Hemonnot-Girard, Cédric Meersseman, Manuela Pastore, Valentin Garcia, Nathalie Linck, Catherine Rey, Amine Chebbi, Freddy Jeanneteau, Stephen D. Ginsberg, Joël Lachuer, Christelle Reynes, François Rassendren, Hélène Hirbec
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Alzheimer’s disease
Amyloid plaques
Inflammation
Laser microdissection
RNA-seq
Online Access:https://doi.org/10.1186/s12974-022-02581-0

Internet

https://doi.org/10.1186/s12974-022-02581-0

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