Synthesis of “<i>All-Cis”</i> Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors

Synthesis of “<i>All-Cis”</i> Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors

Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used at subinhibitory concentrations. Nitrogen-containing glycomimetics such as aza- or iminosugars are known to behave as PCs for lysosomal storage disorders (LSDs). As part of our res...

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Bibliographic Details
Main Authors: Maria Giulia Davighi, Francesca Clemente, Camilla Matassini, Amelia Morrone, Andrea Goti, Macarena Martínez-Bailén, Francesca Cardona
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
synthesis
azasugars
iminosugars
lithium acetylides
lysosomal enzyme inhibitors
lysosomal storage disorders (LSDs)
Online Access:https://www.mdpi.com/1420-3049/25/19/4526

Internet

https://www.mdpi.com/1420-3049/25/19/4526

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