Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes

Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes

Abstract Background Metastatic disease is the major cause of cancer-related deaths. Increasing evidence shows that primary tumor cells can promote metastasis by preparing the local microenvironment of distant organs, inducing the formation of the so-called “pre-metastatic niche”. In recent years, se...

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Bibliographic Details
Main Authors: Marzia Pucci, Marta Moschetti, Ornella Urzì, Marco Loria, Alice Conigliaro, Maria Antonietta Di Bella, Rossella Crescitelli, Roger Olofsson Bagge, Alessia Gallo, Mark F. Santos, Caterina Puglisi, Stefano Forte, Aurelio Lorico, Riccardo Alessandro, Simona Fontana
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Small extracellular vesicles
Transforming growth factor‑β1 (TGFβ1)
Hepatocytes
Liver metastasis
Online Access:https://doi.org/10.1186/s12935-023-02916-8

Internet

https://doi.org/10.1186/s12935-023-02916-8

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