Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.

Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9). In an in vivo glomeru...

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Bibliografski detalji
Glavni autori: Richard A Steinman, Andria Rasile Robinson, Carol A Feghali-Bostwick
Format: Članak
Jezik:English
Izdano: Public Library of Science (PLoS) 2012-01-01
Serija:PLoS ONE
Online pristup:http://europepmc.org/articles/PMC3502367?pdf=render