Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

Summary: Exhausted CD8+ T cells with limited effector functions and high expression of multiple co-inhibitory receptors are one of the main barriers hindering antitumor immunity. The NADase CD38 has received considerable attention as a biomarker of CD8+ T cell exhaustion, but it remains unclear whet...

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Bibliographic Details
Main Authors: Kaili Ma, Lina Sun, Mingjing Shen, Xin Zhang, Zhen Xiao, Jiajia Wang, Xiaowei Liu, Kanqiu Jiang, F. Xiao-Feng Qin, Feng Guo, Baojun Zhang, Lianjun Zhang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Immunology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006186

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http://www.sciencedirect.com/science/article/pii/S2589004222006186

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