The dCache Chemoreceptor TlpA of <named-content content-type="genus-species">Helicobacter pylori</named-content> Binds Multiple Attractant and Antagonistic Ligands via Distinct Sites

The dCache Chemoreceptor TlpA of <named-content content-type="genus-species">Helicobacter pylori</named-content> Binds Multiple Attractant and Antagonistic Ligands via Distinct Sites

ABSTRACT The Helicobacter pylori chemoreceptor TlpA plays a role in dampening host inflammation during chronic stomach colonization. TlpA has a periplasmic dCache_1 domain, a structure that is capable of sensing many ligands; however, the only characterized TlpA signals are arginine, bicarbonate, an...

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Bibliographic Details
Main Authors: Kevin S. Johnson, Bassam A. Elgamoudi, Freda E.-C. Jen, Christopher J. Day, Emily Goers Sweeney, Megan L. Pryce, Karen Guillemin, Thomas Haselhorst, Victoria Korolik, Karen M. Ottemann
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
Helicobacter pylori
chemotaxis
ligand discovery
dCache
signal transduction
chemoreceptor
Online Access:https://journals.asm.org/doi/10.1128/mBio.01819-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01819-21

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