Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia

Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia

Fusion proteins, which consist of factor VIII or factor IX and the transmucosal carrier cholera toxin subunit B, expressed in chloroplasts and bioencapsulated within plant cells, initiate tolerogenic immune responses in the intestine when administered orally. This approach induces regulatory T cells...

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Bibliographic Details
Main Authors: Sandeep R. P. Kumar, Xiaomei Wang, Nagavardhini Avuthu, Thais B. Bertolini, Cox Terhorst, Chittibabu Guda, Henry Daniell, Roland W. Herzog
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
hemophilia
oral tolerance
transgenic plant
regulatory T (Treg) cell
factor IX
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00844/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00844/full

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