Expanding the toolbox of metabolically stable lipid prodrug strategies

Expanding the toolbox of metabolically stable lipid prodrug strategies

Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy. While the literature provides a practical prodrug...

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Bibliographic Details
Main Authors: Kiran S. Toti, Nicole Pribut, Michael D’Erasmo, Madhuri Dasari, Savita K. Sharma, Perry W. Bartsch, Samantha L. Burton, Hannah B. Gold, Anatoliy Bushnev, Cynthia A. Derdeyn, Adriaan E. Basson, Dennis C. Liotta, Eric J. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
prodrugs
HIV
tenofovir
metabolism
lipids
nucleoside
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1083284/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1083284/full

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