Glycosylated clusterin species facilitate Aβ toxicity in human neurons

Glycosylated clusterin species facilitate Aβ toxicity in human neurons

Abstract Clusterin (CLU) is one of the most significant genetic risk factors for late onset Alzheimer’s disease (AD). However, the mechanisms by which CLU contributes to AD development and pathogenesis remain unclear. Studies have demonstrated that the trafficking and localisation of glycosylated CL...

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Bibliographic Details
Main Authors: Evangeline M. Foster, Marco Fernandes, Adria Dangla-Valls, Philip Hublitz, Menelaos Pangalos, Simon Lovestone, Elena M. Ribe, Noel J. Buckley
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23167-z

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https://doi.org/10.1038/s41598-022-23167-z

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