Polycaprolactone Electrospun Scaffolds Produce an Enrichment of Lung Cancer Stem Cells in Sensitive and Resistant EGFRm Lung Adenocarcinoma

Polycaprolactone Electrospun Scaffolds Produce an Enrichment of Lung Cancer Stem Cells in Sensitive and Resistant EGFRm Lung Adenocarcinoma

The establishment of a three-dimensional (3D) cell culture model for lung cancer stem cells (LCSCs) is needed because the study of these stem cells is unable to be done using flat surfaces. The study of LCSCs is fundamental due to their key role in drug resistance, tumor recurrence, and metastasis....

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Bibliographic Details
Main Authors: Emma Polonio-Alcalá, Marc Rabionet, Santiago Ruiz-Martínez, Sònia Palomeras, Rut Porta, Carmen Vásquez-Dongo, Joaquim Bosch-Barrera, Teresa Puig, Joaquim Ciurana
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
NSCLC
cancer stem cells
3D cell culture
electrospinning
CD133
Vimentin
Online Access:https://www.mdpi.com/2072-6694/13/21/5320

Internet

https://www.mdpi.com/2072-6694/13/21/5320

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