Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.

Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.

Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine production, and is considered to play a crucial role in sepsis. Pyroptosis is induced by the two distinct stimuli, microbial PAMPs (pathogen associated molecular patterns) and endogenous DAMPs (damage associated...

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Bibliographic Details
Main Authors: Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3894207?pdf=render

Internet

http://europepmc.org/articles/PMC3894207?pdf=render

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