Electroacupuncture induces weight loss by regulating tuberous sclerosis complex 1-mammalian target of rapamycin methylation and hypothalamic autophagy in high-fat diet-induced obese rats

Electroacupuncture induces weight loss by regulating tuberous sclerosis complex 1-mammalian target of rapamycin methylation and hypothalamic autophagy in high-fat diet-induced obese rats

Background: Obesity can be caused by abnormalities of hypothalamic autophagy, which is closely regulated by the epigenetic modification of TSC1-mTOR. However, whether the weight-reducing effect of EA may relate to the modification of TSC1-mTOR methylation and hypothalamic autophagy remain unclear. T...

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Bibliographic Details
Main Authors: Junpeng Yao, Xiangyun Yan, Xianjun Xiao, Xi You, Yanqiu Li, Yuqing Yang, Wei Zhang, Ying Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
electroacupuncture
obesity
methylation
tuberous sclerosis complex 1
mammalian target of rapamycin
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1015784/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1015784/full

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