Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats

Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats

Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury. Previous studies have demonstrated that inflammasomes act as an important part of the inflammatory process after SCI. Probenecid, an inh...

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Bibliographic Details
Main Authors: Qi Qi, Xiao-Xuan Wang, Jing-Lu Li, Yu-Qing Chen, Jian-Rong Chang, Jin Xi, He-Zuo Lü, Yu-Xin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
probenecid
spinal cord injury
inflammasome
macrophages polarization
immune microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.848185/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.848185/full

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