NF-κB Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation

NF-κB Signaling and IL-4 Signaling Regulate SATB1 Expression via Alternative Promoter Usage During Th2 Differentiation

SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4+ T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of T cells. Although SATB1 function has been subjected to intense investigat...

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Bibliographic Details
Main Authors: Satyajeet P. Khare, Ankitha Shetty, Rahul Biradar, Indumathi Patta, Zhi Jane Chen, Ameya V. Sathe, Puli Chandramouli Reddy, Riitta Lahesmaa, Sanjeev Galande
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
SATB1
alternative promoter
TCR signaling
cytokine signaling
STAT6
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00667/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00667/full

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