Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the gene encoding TDP43 cause familial FTD/ALS. There...

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Bibliographic Details
Main Authors: Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Acta Neuropathologica Communications
Subjects:
Neurodegenerative diseases
Frontotemporal dementia
Amyotrophic lateral sclerosis
TDP43
Alzheimer’s disease
Parkinson’s disease
Online Access:https://doi.org/10.1186/s40478-024-01742-x

Internet

https://doi.org/10.1186/s40478-024-01742-x

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