ORP4L: Can Targeting an MCS Component Provide Tools for Eradication of Leukemia?
The study commented here reports that the OSBP homologue ORP4L is aberrantly induced in CD34 + CD38 − leukemia stem cells (LSCs) of patients with acute myeloid leukemia and acts as an accessory factor for phospholipase C β3 (PLCβ3), a PLC isoform with a dominant role in these cells. Our mechanistic...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-04-01
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| Series: | Contact |
| Online Access: | https://doi.org/10.1177/2515256419840528 |