Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression

Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression

Abstract Cigarette smoke aggravates severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, the underlying mechanisms remain unclear. Here, they show that benzo[a]pyrene in cigarette smoke extract facilitates SARS‐CoV‐2 infection via upregulating angiotensin‐converting enzym...

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Bibliographic Details
Main Authors: Wenbin Liu, Yue Zhao, Junyan Fan, Jiaying Shen, Hailin Tang, Wanda Tang, Di Wu, Weijin Huang, Yibo Ding, Peng Qiao, Jiansheng Lin, Zishuai Li, Qianqian Li, Qianqian Cui, Yan Liu, Yifan Chen, Rui Pu, Xue Han, Jianhua Yin, Xiaojie Tan, Guangwen Cao
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
angiotensin‐converting enzyme 2
cigarettes
coronavirus disease 2019
NR4A2
transmembrane protease serine 2
Online Access:https://doi.org/10.1002/advs.202300834

Internet

https://doi.org/10.1002/advs.202300834

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