Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function

Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function

Joubert syndrome (JBTS) is an inherited autosomal recessive disorder associated with cerebellum and brainstem malformation and can be caused by mutations in the Abelson helper integration site-1 (AHI1) gene. Although AHI1 mutations in humans cause abnormal cerebellar development and impaired axonal...

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Bibliographic Details
Main Authors: Louyin Zhu, Laiqiang Chen, Lingya Yan, Brian D. Perkins, Shihua Li, Baoming Li, Hong A. Xu, Xiao-Jiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
axonal decussation
AHI1
CRISPR/Cas9
coiled-coil
gain of function
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00081/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00081/full

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