Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis

Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis

Abstract Background Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease associated with metabolic dysfunction and age-related mechanisms, with progressive accumulation of senescent cells and compromised ADSC func...

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Bibliographic Details
Main Authors: L K Grun, R M Maurmann, J N Scholl, M E Fogaça, C R R Schmitz, C K Dias, J Gasparotto, A V Padoin, C C Mottin, F Klamt, F Figueiró, M H Jones, E C Filippi-Chiela, F C R Guma, F M Barbé-Tuana
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Immunity & Ageing
Subjects:
Mesenchymal stem cell
Senescence
Obesity
Chronic inflammation
Mitochondria
Online Access:https://doi.org/10.1186/s12979-023-00378-0

Internet

https://doi.org/10.1186/s12979-023-00378-0

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